Results
| PMID | 2910718 |
| Gene Name | MUC16 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 326 |
| Population details | 326 (163 women who had had pelvic pain, 82 women with endometriosis, 81 women without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | CA-125 |
| Other associated phenotypes |
Endometriosis, chronic pelvic pain |
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Fertil Steril. 1989 Jan;51(1):68-70. Pittaway, D E| Douglas, J W Department of Obstetrics and Gynecology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27103. Since serum CA-125 concentrations are increased in women with endometriosis, the authors evaluated CA-125 levels to determine whether this serum test would be useful in differentiating between pelvic pain due to endometriosis and other causes. During a 30-month period, 163 women who had had pelvic pain for at least 3 months had a CA-125 level obtained prior to surgery. Serum CA-125 was measured by an immunoradiometric assay. Of the 82 women with endometriosis, 66 (80%) had CA-125 concentrations greater than or equal to 16 U/ml (95% upper limit). The frequencies of elevated levels in minimal, mild, moderate, and severe endometriosis were 52, 86, 100, and 100%, respectively. Of the 81 women without endometriosis, 5 (6%) had elevated concentrations. With the use of serum CA-125 determinations for the detection of endometriosis, the sensitivity was 80%, the specificity was 94%, and the accuracy was 93% when the prevalence of endometriosis was 50%. The authors conclude that determination of CA-125 levels may assist in the evaluation and treatment of women with chronic pelvic pain. Mesh Terms: Adolescent| Adult| Antigens, Tumor-Associated, Carbohydrate/*analysis| Chronic Disease| Diagnosis, Differential| Endometriosis/*diagnosis/physiopathology| Female| Humans| Pain/*etiology| Pelvic Neoplasms/*diagnosis/physiopathology| *Pelvis| Pre |
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